Can less be more? A heretical approach to chemotherapy is extending cancer patients’ lives

first_img Tags cancerpharmaceuticalsresearchSTAT+ Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. Senior Writer, Science and Discovery (1956-2021) Sharon covered science and discovery. Dr. Robert Gatenby in his office at Moffitt Cancer Center in Tampa, Fla. Tina Russell for STAT GET STARTED Sharon Begley Health @sxbegle STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Can less be more? A heretical approach to chemotherapy is extending cancer patients’ lives center_img No scientist with even a rudimentary moral compass and an ounce of intellectual humility takes human experiments lightly, given how much can go wrong. But Dr. Robert Gatenby was especially aware of the stakes.An oncologist at Moffitt Cancer Center in Tampa, Fla., he has spent years studying how tumor cells respond to chemotherapy, especially in patients whose cancer has metastasized well beyond the original tumor, as when malignant prostate cells invade bones like gang members expanding their turf. Now Gatenby was ready to put his theories to a real-world test by treating men with advanced prostate cancer in a way that broke all the rules. Log In | Learn More Unlock this article — and get additional analysis of the technologies disrupting health care — by subscribing to STAT+. First 30 days free. GET STARTED What is it? About the Author Reprints What’s included? By Sharon Begley Aug. 29, 2019 Reprints [email protected] last_img read more

Fresh Effort Needed for Refugee Support

first_img By Daily NK – 2009.12.03 5:52pm News Entire border patrol unit in North Hamgyong Province placed into quarantine following “paratyphoid” outbreak News News AvatarDaily NKQuestions or comments about this article? Contact us at [email protected] [imText1]The treatment of physical and psychological disorders should be prioritized in order to increase the labor power of North Korean refugees in South Korea and to foster their economic independence.A professor of social work at Daegu University, Kim Yeon Hee believes, “The influence of not only mental health issues resulting from a variety of violent and traumatic incidents, but also addictive behaviors such as alcoholism arising in their aftermath, on the ability of refugees to lead self-supporting lives is huge.” Kim was talking at “A Special Symposium for the Era of 20,000 North Korean Breakaway Citizens,” an event on the 2nd sponsored by the National Human Rights Commission of Korea and the Center for North Korean Defectors. Professor Kim emphasized the importance of maintaining the health of refugees, saying, “The health condition of recent refugees who were in their childhood during the food shortage in the mid-1990s is known to be extremely weak. After being released from Hanawon, nutrition and illness-related health problems cause the condition of many to deteriorate, resulting in their incapacitation.”She contrasted the Korean situation with the U.S. refugee assistance systems, emphasizing that in the U.S. “interventionist measures regarding physical and mental health are actively implemented, and treatment to remove factors that can pose a handicap to refugees’ independence have become essential.”“The predominance of females among refugees in recent years means an influx of the most destitute population but, fortunately, most of the women are in their 20s~30s, which eliminates the dual factors of being a woman and advanced age. However, the number of female heads of household with young children is on the rise, resulting in a vulnerable situation where a majority remain economically inactive,” she went on. “Investment in human capital is important. In particular, diverse psychological and societal educational support services and mid-way drop-out prevention programs are critical anti-poverty policies which can guard against a vicious cycle of poverty,” she elaborated.Lee Ki Young, a professor of social work at Pusan University, explained, “After allowing the admission and resettlement of refugees, the U.S. focuses on their employment and economic success, and the Office of Refugee Resettlement (ORR) under the federal government has organized a taskforce for promoting the economic independence of refugees. In South Korea, self-support and independence are proposed as the items of utmost priority.”But he pointed out, “In South Korea, where even low-level employment isn’t guaranteed for the refugees, whether or not to pursue an early stage policy for promoting independence such as in the U.S. should be carefully considered. In particular, many North Korean breakaway citizens have debts after using brokers before entering South Korea, so their actual economic situation is quite precarious and they have a high desire for an income to bring in additional family members, but it is difficult to find ideal results from work.”“In South Korea’s case… employment aid programs which provide opportunities for one to climb in the workplace, as well as institutional supplements that can guarantee the integrity and increase the gains from employment, should be strengthened,” he proposed.Additionally, “We have to make an effort so that the localization of resettlement support can be achieved. To achieve this, three-way collaboration between central government, provincial governing bodies and civilian organizations should be strengthened, and budgetary distribution and work responsibilities ought to be effectively realized.”Lee Geum Soon, a senior researcher at the Korea Institute for National Unification, agreed, “The number of North Korean breakaway citizens differs significantly by region, so it is important, at the very least, to build a system which allows the provision of standardized service unrelated to the refugees’ region of resettlement,” he asserted, “There has been interest from central ministries and offices at the policy level, and even institutional supplements are in place, but interest among regional units has to increase.” RELATED ARTICLESMORE FROM AUTHORcenter_img Facebook Twitter There are signs that North Korea is running into serious difficulties with its corn harvest North Korea tries to accelerate building of walls and fences along border with China Fresh Effort Needed for Refugee Support News SHARElast_img read more

Former rep gets four-year trading ban for high closing

first_img Mouth mechanic turned market manipulator Keywords Enforcement,  Market manipulationCompanies Raymond James Ltd., Alberta Securities Commission Related news “The practice of repeatedly entering high bids late in the trading day, leading to high close trades or uptick bid prices, is a manipulative strategy,” the settlement noted.“The placing and the timing of such bids are driven not by bona fide trading motives, but a desire to influence other traders by creating the impression a stock did well in trading during the day,” it adds.Thor agreed to a four-year trading ban, a $30,000 fine and to pay $10,000 in costs to settle the case.According to the settlement with the ASC, Thor “repeatedly entered bids on behalf of a client for shares late in the trading day that were higher than the last trade of the day, resulting in at least 25 high close transactions.”“Thor admitted that he ought to have known that the high close purchases may result in, or contribute to, a false or misleading appearance of trading activity and an artificial price for a security,” the regulator said.The settlement noted that Thor had not been previously sanctioned, and cooperated with the ASC’s investigation. Share this article and your comments with peers on social media PwC alleges deleted emails, unusual transactions in Bridging Finance case James Langton BFI investors plead for firm’s sale High angle view of mallet eyeglasses legal book in courtroom andreypopov/123RF Regulators in Alberta have sanctioned a former rep for “high closing” trades that he placed on behalf of a client.The Alberta Securities Commission (ASC) has announced a settlement with Henry Ian Thor, a former rep at Raymond James Ltd. in Edmonton, who admitted to violating securities rules by repeatedly making trades in a venture stock, BCM Resources Corp., that resulted in high closes. Facebook LinkedIn Twitterlast_img read more

India’s Airtel, Idea agree to give 4G upstart Jio additional access

first_img Asia Previous ArticleSamsung heir set to expand role in wake of recallNext ArticleVodafone to inject $3B in India unit – report Joseph Waring Related Author Joseph Waring joins Mobile World Live as the Asia editor for its new Asia channel. Before joining the GSMA, Joseph was group editor for Telecom Asia for more than ten years. In addition to writing features, news and blogs, he… Read more AirtelIdea CellularIndiainterconnectReliance jio Jio to acquire 800MHz spectrum from Airtel for $204Mcenter_img Jio profit soars on subscriber gains India to shun China vendors in 5G trials Tags India’s number one and three mobile players Bharti Airtel and Idea Cellular agreed to provide 4G upstart Reliance Jio with additional interconnection points.Airtel said in a statement it will expand interconnect access by threefold to support up to 15 million Jio customers, while Idea said it will release an additional 196 interconnection points, which is sufficient to handle calls from 6.5 million users, the Economic Times reported.The agreement comes just days after the Telecom Regulatory Authority of India (TRAI) told Jio and the three incumbents to work out a resolution and warned it would intervene if quality of service suffered.For more than a month Jio has accused the country’s incumbent operators of deliberately sabotaging its entry by not providing it with adequate points of interconnection, which forced it to delay its commercial launch.Jio issued a statement last night complaining that service quality had deteriorated significantly in the last few weeks, with more than 75 calls failing out of every 100 call attempts. In the last 10 days alone, it said 520 million calls have failed on the networks of the three leading incumbent operators, with 42 per cent on Airtel’s network.Both Airtel and Idea said they expect a huge imbalance in inbound and outbound traffic, but Jio said voice traffic on its network is in line with industry trends for a new operator. “When a new operator begins, its customer base is understandably low. Therefore, in the early days of any new operator, there are more outgoing calls than incoming calls. Over time, as the customer base grows, this asymmetry reduces and the traffic becomes symmetric.”Last month Jio requested 12,000 interconnection points to handle its expected 22 million customers, but the incumbents only gave it 1,400, the Times said.The newcomer started commercial 4G operation across the country’s 22 service regions on 5 September, offering subscribers free unlimited LTE data and national voice, video and messaging services until the end of the year.Its aggressive move will likely start a price war, with major rivals reportedly set to respond with packages that beef up their own data offerings. HomeAsiaNews India’s Airtel, Idea agree to give 4G upstart Jio additional access AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 14 SEP 2016 last_img read more

Adult Spelling Bee

first_img0:30 | Play story Add to My ListIn My List For Whom The Bell Rings Legal Advocate Discusses Medical Abuse At Shut Down Georgia ICE Facility 0:30At Manuel’s Tavern in Midtown, the Atlanta Open Orthographic Society holds an annual written spelling bee. But this bee is not for young people, and it’s not associated with a local school. In fact, it takes place in a bar. Share Related Stories ‘It’s Fractured’: Georgia Lt. Gov. Geoff Duncan On Healing Republican Partylast_img read more

15 Central Park West penthouse sells for $46.7M

first_img Email Address* 15 Central Park West penthouse and Lindsay Rosenwald (Google Maps, BHS, Fortress)A sprawling penthouse at 15 Central Park West sold on Tuesday for $46.67 million, 28 percent less than its first asking price.The 5,902-square-foot duplex is on the 18th and 19th floors of the renowned condominium designed by architect Robert A.M. Stern.The property went into contract and closed in one day to an unknown buyer who purchased the unit through a Delaware-registered limited liability company.Read moreExtell sells One57 sponsor unit for $17M“We are recovering”: Manhattan home sales finally increaseDeep discounts for “bottom fishers”: How 3 deals show the state of Manhattan’s buyer’s market The seller was Dr. Lindsay Rosenwald, the chief executive of pharmaceutical company Fortress Biotech. He bought the unit in 2008 for $30.5 million and put it on the market in September 2019 for $65 million.Listing broker Felise Gross of Brown Harris Stevens said Rosenwald listed the penthouse because he “just wasn’t using it.”The unit’s 19 months on the market included three months early in the pandemic when home showings were banned, but the length of the listing likely had more to do with aspirational pricing and doubts about Manhattan and its luxury market, which has only recently begun to recover from a multi-year slump.The transaction also included a studio apartment for staff, a wine cellar and two storage units.Gross, who represented Rosenwald with BHS brokers David Kornmeier and Diane Abrams, dropped the asking price in January by 11 percent to $57.9 million. Though the final sales price was more than $11 million lower, Gross said the doctor was happy with the deal. He received $16 million more for the duplex than he paid.“In this market I think the seller was very happy and he did very well,” she said. “The apartment is one of the finest in New York.”The unit has an internal private elevator, five bedrooms, 1,070 square feet of outdoor terraces overlooking Central Park, a gas fireplace and south- and west-facing views.Sales in Manhattan have picked up in recent months as sellers and developers accept discounted offers from buyers aiming to capitalize on the moment.Contact Erin Hudson Full Name* Message*last_img read more

First Look! 2011 Easton EC90 Aero Carbon Clincher Road Wheels, New 90mm Tri Version…

first_imgDespite the deep rim, the claimed weight is just 1670g for the set. Shown here is Easton’s new road carbon clincher with a 56mm deep rim versus prior (and still available) 38mm model. Stiffer and a bit more aero, it will retail for $2,000 and start shipping in early 2011.It uses their proprietary ThermaTec braking track treatment to reduce heat buildup under hard, long braking and provide better modulation.  The rim is molded into its final shape in one single process, which Easton says gives it better strength and impact resistance than competing brands. (remember that smashed Easton wheel that Hincapie finished a stage of the ATOC on?)Bigger news: Shortly after the 56mm versions hit retail, they’ll launch a 90mm deep version aimed at triathletes. Those will have their R4 hubset with stainless steel bladed Sapim spokes and alloy nipples.Full specs and more pretty pics after the break…last_img read more

Wanted Florida Man Captured in Great Smokies

first_imgA wanted Florida man was caught after an extensive manhunt in the Great Smoky Mountains National Park on Friday. On February 16, 2017, a park ranger pulled over a car at Little River Road near the Meigs Falls area at around 3 p.m. Officials said the adult male driver ran through the woods across Little River Road. The man was identified as Noah J. Davis of Putnam County, Florida. Authorities said Davis was wanted on an active warrant for violating parole conditions. Great Smoky Mountains officials worked with Knox, Sevier and Blount County officers throughout the night to search for Davis using canine units, aerial support, and the forward looking infrared radar to find Davis. Officials said Davis is being treated for minor injuries.last_img read more

Marshfield Senior Legion baseball roughs up Plover for sixth-straight win

first_imgBlue Devils now 19-4, host Eau Claire for two WednesdayBy Paul LeckerSports ReporterMARSHFIELD — The Marshfield Clinic Post 54 Senior American Legion baseball team is not just hot. It is scorching.The Blue Devils ripped out 16 hits, batted around in two separate innings, and rolled past Plover 20-7 in a Wisconsin Valley Legion League matchup Tuesday night at Jack Hackman Field.Marshfield, ranked fifth in this week’s Class AAA state rankings, has won 11 of its last 12 games, including six in a row, and is now 19-4 and 7-2 in the WVLL. The Blue Devils wrap up their regular-season schedule with a nonleague doubleheader against second-ranked Eau Claire on Wednesday and a WVLL game against Wausau on Thursday, both at home.Heading into the Class AAA regionals July 19-22 and the state tournament July 26-30, which will both be at Hackman Field, the Blue Devils are showing they are a team to be reckoned with in the postseason.“As a team we are hitting right around .400, and tonight we had 16 hits, no errors,” Marshfield coach Tom Sorenson said. “I told the kids in the beginning we have a great defense, so the pitcher has to keep that in mind. You don’t have to strike everybody out. Challenge the hitters, and it’s working.”Marshfield jumped on Plover starting pitcher Cam Lee, chasing him from the game before he got out of the first inning.An error, three walks, and five hits led to nine runs in the opening inning for the Blue Devils. Jack Donahue had a sacrifice fly to score the first run; Mitch Susa, Paul Maguire, Nate McDonald, and Trevor Schwecke had RBI singles in the frame; and Braden Bohman added a two-run single for Marshfield.Hunter Luepke added a two-run double in the second to make it 11-2.Maguire clubbed a home run to lead off the fourth — Bohman and Schwecke also had RBI singles in the inning — before Marshfield put the game out of reach with sixth more in the fifth, highlighted by a three-run double by Donahue.“This year we had a lot of new players from Stratford, Greenwood, a lot of new players,” said Schwecke, the Blue Devils’ shortstop. “It’s always awkward at first because you don’t know everybody, but once we got it together we found it … the last 10 or 12 games with the run we’ve made.”Donahue allowed five runs in six innings, striking out 10, to earn the victory to improve to 4-1 this season. He also has 39 strikeouts in 36 2/3 innings pitched, leading the team in both categories. His three RBIs also gives him a team-best 36 RBIs in 23 games.Bohman, Schwecke, and Maguire each had three hits; seven of the Blue Devils’ nine starters drove in at least one run; and all but one starter scored at least once.(Hub City Times Sports Reporter Paul Lecker is also the publisher of MarshfieldAreaSports.com.)Blue Devils 20, Black Sox 7Plover 020 003 2 – 7 8 2Marshfield 920 360 x – 20 16 0WP: Jack Donahue. LP: Cam Lee.SO: Lee (2/3 inn.) 1, Gavin Erbes (3 1/3 inn.) 4, Carter Newby (2 inn.) 2; Donahue (6 inn.) 10, Trevor Schwecke (1 inn.) 1. BB: Lee 3, Erbes 1, Newby 1; Donahue 4, Schwecke 1.Top hitters: P, Aaron Baker 2×2, 2 runs; Newby 2×2, 2B, 3 RBIs. M, Nate McDonald 2×5, 4 runs; Braden Bohman 3×4, 3 runs, 3 RBIs; Schwecke 3×4, 2 runs, 2 RBIs; Donahue 2B, 3 RBIs; Mitch Susa 2×4, 3 runs; Paul Maguire 3×5, HR, 4 runs, 2 RBIs; Bobby Pilz 2 runs; Hunter Luepke 2B, 2 RBIs.Records: Plover not reported; Marshfield 19-4, 7-2 Wisconsin Valley Legion League.last_img read more

Chan 2014: Make us proud, Mbalula tells Bafana

first_img9 January 2014South African Minister of Sport and Recreation Fikile Mbalula has wished Bafana Bafana well ahead of the Orange Caf African Nations Championship (Chan), which kicks off at the Cape Town Stadium on Saturday.South Africa tackle Mozambique in the tournament’s opening match. They also face Mali on 15 January and Nigeria on 19 January at the same venue to complete their fixtures in Group A.WarningMbalula visited the Bafana squad at their base camp in Cape Town on Tuesday to offer words of encouragement before the start of the tournament. He also sounded a warning, telling the players: “If you go with the mentality that teams have not sent strong players here you are going to be surprised by Mozambique. They will want to come here and embarrass you.“And you don’t want to appear as people who did not give their all and did not want to represent their country. I thought I needed to emphasise that point that we have pride in you, and we are confident that all of you will make this country of ours proud. Rewards come at the end, not at the beginning.”Important competitionThe teams competing in the African Nations Championship are made up of players who ply their trade in their home countries. Mbalula said the competition is crucial for the growth of the South African national team.“Anyone who says this competition is not serious is making a big mistake and misleading the country. This competition is taking place in South Africa and is a very important competition.“All the 16 teams that are coming here have not been invited or co-opted or asked by Caf to come here. They had to compete to get here. They earned their right to be in South Africa with us. It is time for the people of South Africa to have pride,” he added.“You are going to compete with the best on the African continent. This is our path and journey to glory. It starts with Chan.”SupportBafana Bafana captain Itumeleng Khune responded to Mbalula’s address, saying: “We are going to go out there with the knowledge that we have your support and the country’s. As players we need to inform you that we are taking this tournament very seriously and will do our best to ensure great results.”Midfielder Siphiwe Tshabalala, the most experienced member of the squad, with 85 caps to his name, on Wednesday told the media a good result in Bafana’s opening match was vitally important.‘Crucial’“Every match we play is important,” he said, “but the first game is very crucial because it is always good to start the tournament on a high. A win sets a very nice tone for the rest of the competition. It is good for the team’s morale and for the fans.”Tshabalala also expressed confidence in South Africa’s preparations. “The stakes and the expectations are high for us to do well. I believe we are ready after days of hard work and will continue doing so in the remaining two days. I am positive that the 11 players that will be selected to do the job on Saturday will succeed,” he said.Striker Katlego Mphela echoed Tshabalala’s sentiments, saying: “We want to do well in every game we play. We are raring to go. We know what we have to do and we are well aware how important the first match is. We have to start with a bang.”Late changeMeanwhile, coach Gordon Igesund was forced into a late change to his squad on Wednesday because of an injury to Jabulani Shongwe, who was replaced by Matty Pattison.Commenting on the change, Igesund said: “It is never good to lose any player, especially through injury, but I am sad to say Shongwe will no longer be a part of us for this tournament due to a tear that won’t heal in time for the tournament, so we have had to withdraw him from the squad.“But I believe I have found a perfect replacement in Pattison. Unfortunately, injuries are part of the game and we have to soldier on.”last_img read more